The 2005–06 A1 Grand Prix of Nations, South Africa was an A1 Grand Prix race, held on the weekend of 29 January 2006 at a street course in Durban, South Africa.

Ananda Mikola driving for A1 Team Indonesia was fastest in the first session with a time of 1:28.477.

Will Davison from A1 Team Australia was fastest in the second session with a time of 1:30.520.

During the third practice, on Saturday, A1 Team Pakistan driver Adam Khan was involved in a serious crash, forcing a helicopter flight to the nearest hospital for precautionary CT scans.

These scans showed negative, but Khan was unable to compete in the remainder of the weekend's events, replaced by A1 Team Italy's backup driver, Enrico Toccacelo but Pakistan would not score points.