It began on 28 August 2005 with the preliminary round and ended on 10 May 2006 with the Final match.
Teuta were the defending champions, having won their third Albanian Cup last season.
[1] The rounds were played in a two-legged format similar to those of European competitions.
If the aggregated score was tied after both games, the team with the higher number of away goals advanced.
If the number of away goals was equal in both games, the match was decided by extra time and a penalty shootout, if necessary.