The 2005–06 Bucknell Bison men's basketball team represented Bucknell University during the 2005–06 NCAA Division I men's basketball season.

The Bison, led by head coach Pat Flannery, played their home games at Sojka Pavilion and were members of the Patriot League.

They finished the season 27–5, 14–0 in Patriot League play to win the conference regular season title by three games.

They won the Patriot League tournament to earn an automatic bid to the 2006 NCAA tournament where they defeated No.

[2] This was the second straight season the Bison reached the round of 32 of the NCAA Tournament.