2005–06 Campionato Sammarinese di Calcio

The 2005–06 Campionato Sammarinese di Calcio season is its twenty-first since its establishment.

The top three clubs from each girone will compete in a playoff tournament.

[1] The first round winners play the first place clubs from each group.

The winner advances to the finals and loser moves to the semifinals.

[1] The winner advances to the finals and the loser is eliminated.