The Huskies were members of the Big East Conference where they finished with a 14–2 record and were the regular season champions.

They made it to the Elite Eight in the 2006 NCAA Division I men's basketball tournament.

The Huskies played their home games at Harry A. Gampel Pavilion in Storrs, Connecticut and the Hartford Civic Center in Hartford, Connecticut, and they were led by twentieth-year head coach Jim Calhoun.

[4] Their Elite Eight matchup found themselves facing the George Mason Patriots.

The Patriots were able to defeat the top-seeded Huskies, 86–84 in overtime, in what is recognized as one of the most memorable games in tournament history.