AEM Mesogis won their 1st title.
Fourteen teams participated in the 2005–06 Cypriot Third Division.
The team with the most points at the end of the season crowned champions.
The first three teams were promoted to the 2006–07 Cypriot Second Division and the last three teams were relegated to the 2006–07 Cypriot Fourth Division.
Teams promoted to 2005–06 Cypriot Second Division Teams relegated from 2004–05 Cypriot Second Division Teams promoted from 2004–05 Cypriot Fourth Division Teams relegated to 2005–06 Cypriot Fourth Division