The 2005–06 Divizia C was the 50th season of Liga III, the third tier of the Romanian football league system.
Victoria Muntenii de Jos were replaced by Willy Bacău.
Navol Oltenița were replaced by Gloria ANEFS București.
ASA Târgu-Mureș was dissolved and replaced by Maris Târgu Mureș.
As a result, their satellite Deva II, who were also playing in the third tier, were removed.