The 2005–06 FA Women's Premier League Cup was the 15th edition of the FA Women's Premier League's league cup competition, which began in 1991.
It was sponsored by Nationwide and was officially known as the FA Nationwide Women's Premier League Cup.
Charlton Athletic won their second title after a 2–1 win over Arsenal in the final.
All results listed are published by The Football Association (FA).
The matches were played on 11 September 2005, the only exception being Arsenal v Wolverhampton Wanderers, which took place on 2 October 2005.