They were led by head coach Billy Donovan, and played their home games in the O'Connell Center on the university's Gainesville, Florida campus.

The Gators started the season looking to end their recent streak of losing in the first two rounds of the NCAA tournament.

They finished the season with a 24–6 record entering the SEC Championship.

3 seed in the NCAA tournament, eventually playing in the final against UCLA.

On April 3, 2006, Florida beat UCLA 73–57 to win their first ever NCAA Championship.