The team achieved several milestones, including a team-record 23 regular season wins, and earned an at-large bid to that year's NCAA tournament.

In the NCAA Tournament, the Patriots reached the Final Four, becoming the first team from the Colonial Athletic Association to accomplish that feat.

[9] Their Elite Eight matchup found themselves facing the Connecticut Huskies, a team that was tabbed as the favorite to win the national championship the entire season.

Their tournament run would end in Indianapolis, in a Final Four matchup with the Florida Gators, the eventual national champion in both 2006 and 2007 (with the same starting lineup both years).

George Mason's Cinderella story ended in Indianapolis, when the eventual National Champion Florida Gators defeated them 73–58 on April 1, 2006.