The competition started on 20 August 2005 and concluded on 10 May 2006 with the Final, held at Pankritio Stadium.
Olympiacos won the trophy with a 3-0[1] victory over AEK Athens.
Each tie in the knockout phase, apart from the quarter-finals and the semi-finals, was played by a single match.
The team that scored more goals on aggregate over the two legs advanced to the next round.
If no goals were scored during extra time, the winners were decided by a penalty shoot-out.