The 2005–06 Hampton Pirates men's basketball team represented Hampton University during the 2005–06 NCAA Division I men's basketball season.

The Pirates were members of the Mid-Eastern Athletic Conference and were coached by Bobby Collins, his fourth and final year as head coach.

The Pirates played home games at the Hampton Convocation Center.

The Pirates won the MEAC tournament to earn the conference's automatic bid to the NCAA tournament.

16 seeds in the Midwest region, Hampton was beaten by fellow No.