The 2005–06 Iona Gaels men's basketball team represented Iona College during the 2005–06 NCAA Division I men's basketball season.

The Gaels, led 8th-year by head coach Jeff Ruland, played their home games at the Hynes Athletic Center and were members of the Metro Atlantic Athletic Conference.

The Gaels finished second in the MAAC regular season standings, and would go on to win the MAAC Basketball tournament to receive an automatic bid to the 2006 NCAA tournament.

13 seed in the South region, the Gaels lost to No.

4 seed and eventual Final Four participant LSU in the opening round.