The 2005–06 Iowa State Cyclones men's basketball team represented Iowa State University during the 2005–06 NCAA Division I men's basketball season.

The Cyclones were coached by Wayne Morgan, who was in his 3rd season.

They played their home games at Hilton Coliseum in Ames, Iowa and competed in the Big 12 Conference.

[2] They lost to Texas Tech in the quarterfinals of the Big 12 tournament.

They received an at-large bid to the NCAA tournament where they defeated Minnesota and lost to North Carolina.