87 teams contested, beginning on 2 August 2005 and ending at the final on 7 May 2006.
Ajax beat PSV 2–1 in the final, winning the trophy for the sixteenth time.
They had previously been playing in the Champions League and UEFA Cup.
E six Eredivisie entrants Both Ajax and PSV already secured a Champions League spot in the national competition.
Therefore, the UEFA Cup ticket the winner of this tournament would win, could now be won in the Eredivisie play-offs.