[2] Manang Marsyangdi Club won the league.

The season began on 26 August 2005 and concluded on 21 February 2006.

APF Club made their debut in the league without being promoted before.

[2] On matchday 27, relegation-threatened Machhindra FC faced Ranipokhari Corner Team.

After the match ended 9-8 for Machhindra, allegations of match fixing rose, as Machhindra needed the win while RCT's Rishi Rai, who scored all eight goals, was on course to become the league's top goalscorer.