The 2005–06 Munster Rugby season was Munster's fifth season competing in the Celtic League, alongside which they also competed in the Heineken Cup.
It was Declan Kidney's first season as head coach, in his second spell at the province.
Note: Flags indicate national union under World Rugby eligibility rules.
Players may hold more than one non-World Rugby nationality.
Note: Munster took first place over Sale Sharks on competition points in head-to-head matches, 5–4.