The 2005–06 Murray State Racers men's basketball team represented Murray State University during the 2005–06 NCAA Division I men's basketball season.

The Racers, led by third-year head coach Mick Cronin, played their home games at Racer Arena in Murray, Kentucky, as members of the Ohio Valley Conference.

They finished the season 24–7, 17–3 in OVC play to win the OVC regular season title.

14 seed in the Washington, D.C. region, the Racers were narrowly beaten by No.

3 seed and defending National champion North Carolina, 69–65.