The 2005–06 regular season took place over 23 rounds between 2 September 2005 to 5 February 2006.

Source: NBL.com.au The NBL tie-breaker system as outlined in the NBL Rules and Regulations states that in the case of an identical win–loss record, the results in games played between the teams will determine order of seeding.

The MVP was awarded to Chris Anstey of the Melbourne Tigers.

[1] The Grand Final MVP was also awarded to Chris Anstey.

The Rookie of the Year went to Mark Worthington of the Sydney Kings.