The 2005–06 season of the NOFV-Oberliga was the twelfth season of the league at tier four (IV) of the German football league system.
The NOFV-Oberliga was split into two divisions, NOFV-Oberliga Nord and NOFV-Oberliga Süd.
The champions of each, 1.
FC Union Berlin and 1.
FC Magdeburg, were directly promoted to the 2006–07 Regionalliga Nord.