New teams to the division included Henley Hawks and Orrell who were relegated from the 2004–05 National Division One, Halifax who were promoted from the 2004–05 National Division Three North as well as Barking (champions) and Redruth (runners up) who were promoted from the 2004–05 National Division Three South.

[1][2][3][4][5] Only one team would be relegated at the end of this season (instead of the usual three).

By the end of the season Moseley were league champions beating Waterloo to first place by just 2 points, with both sides being promoted to the 2006–07 National Division One.

[6][7] Orrell finished as the league's bottom side behind 13th place Harrogate and were relegated to the 2006–07 National Division Three North, making it two consecutive relegations for the Wigan based club.

59 - 6 Esher at home to Halifax on 28 January 2006 43 - 3 Waterloo away to Stourbridge on 29 October 2005 59 - 6 Esher at home to Halifax on 28 January 2006 Esher at home to Halifax on 28 January 2006 Esher at home to Halifax on 28 January 2006 Barking at home to Manchester on 17 September 2005 Launceston at home to Blackheath on 21 January 2006 Henley Hawks at home to Barking on 11 February 2006 [11][12][13] [14] Corrado Pilat for Barking at home to Manchester on 17 September 2005 Stuart Alred for Launceston at home to Blackheath on 21 January 2006 Felise Ah-Ling for Barking at home to Launceston on 3 September 2005 Nathan Bressington for Moseley away to Harrogate on 18 February 2006 Matthew Leek for Esher at home to Halifax on 28 January 2006 Corrado Pilat for Barking at home to Manchester on 17 September 2005 Stuart Alred for Launceston at home to Blackheath on 21 January 2006 N/A - multiple players [15][16][17][18][19] Redruth at home to Launceston on 18 March 2006 Barking at home to Wharfedale on 3 December 2005 Redruth Barking [20]