The 2005–06 Northern Premier League season was the 38th in the history of the Northern Premier League, a football competition in England.
In the thirty-eighth season of the Northern Premier League Blyth Spartans (as champions) and Farsley Celtic (as play-off winners) were promoted to the Conference North.
Wakefield, Bradford Park Avenue and Runcorn Halton were relegated to the First Division; these three clubs were replaced by relegated Conference North side Hednesford Town, First Division winners Mossley, second placed Fleetwood Town and play-off winners Kendal Town.
In the First Division Bishop Auckland were relegated and were replaced by Buxton, Cammell Laird, Harrogate Railway Athletic, Alsager Town and Skelmersdale United.
Peter Swales Shield: Between Champions of NPL Premier Division and Winners of the NPL Cup.