The 2005–06 Old Dominion Monarchs basketball team represented Old Dominion University in National Collegiate Athletic Association (NCAA) Division I men's basketball during the 2005–06 season.

Playing in the Colonial Athletic Association (CAA) and led by fifth-year head coach Blaine Taylor, the Monarchs finished the season with a 24–10 overall record (13–5 CAA).

The Monarchs competed in the 2005 Paradise Jam and lost to Wisconsin in the in-season tournament championship after winning their first two round-robin games.

After losing to Northeastern in the CAA tournament quarterfinal, Old Dominion received a qualifying bid to the 2006 National Invitation Tournament.

5 seed in the Maryland bracket, ODU proceeded to winning out the bracket after defeating Hofstra in the tournament quarterfinal.