The 2005–06 Quaid-e-Azam Trophy was one of three first-class domestic cricket competitions that were held in Pakistan during the 2005–06 season.

The Quaid-e-Azam Trophy was contested by thirteen teams representing regional associations;[a] it was followed in the schedule by the Patron's Trophy Grade-I, contested by ten departmental teams,[a] and the revived Pentangular Trophy, involving the top teams from each competition, later in the season.

[1][2][3] Sialkot won the Quaid-e-Azam Trophy for the first time, after they beat Faisalabad by an innings and 44 runs in the Gold League final.

[4] Karachi Harbour won the Silver League final to earn promotion, and Multan were relegated from the top division.

The top two teams in the round-robin group stage (highlighted) advanced to the finals.