The 2005–06 season was the 106th season in Società Sportiva Lazio's history and their 18th consecutive season in the top-flight of Italian football.

Lazio finished Serie A in 6th place, but were later placed in 16th, just above the relegation zone due to involvement in the 2006 Italian football scandal.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

Players may hold more than one non-FIFA nationality.