The 2005–06 Slovak Cup was the 37th season of Slovakia's annual knock-out cup competition[1] and the thirteenth since the independence of Slovakia.

It began on 2 August 2005 with the matches of first round and ended on 8 May 2006 with the final.

The winners of the competition earned a place in the first qualifying round of the UEFA Cup.

Dukla Banská Bystrica were the defending champions.

The first legs were played on 18 October 2005 with the exception of Artmedia Bratislava – FC Senec, which was played on 5 October 2005.