The 2005–06 Spartan South Midlands Football League season is the 9th in the history of Spartan South Midlands Football League a football competition in England.
The Premier Division featured 17 clubs which competed in the division last season, along with three new clubs: Also, Haywood United changed name to Aylesbury Vale.
Division One featured 14 clubs which competed in the division last season, along with three new clubs:
Division Two featured 15 clubs which competed in the division last season, along with three new clubs: Also, Padbury B T F C changed name to Padbury United.