The 2005–06 UAB Blazers men's basketball team represented the University of Alabama at Birmingham as a member of the Conference USA during the 2005–06 NCAA Division I men's basketball season.
This was head coach Mike Anderson's fourth season at UAB, and the Blazers played their home games at Bartow Arena.
They finished the season 24–7, 12–2 in C-USA play and lost in the semifinals of the C-USA tournament.
They received an at-large bid to the NCAA tournament as No.
The Blazers fell in the opening round to No.