The qualifying rounds for the 2005–06 UEFA Cup began on 14 July 2005.
In the qualifying rounds, UEFA divided the participating teams into three geographical regions: Northern, Central–East, and Southern–Mediterranean.
This meant that a club potentially seeded in an open draw format could be unseeded in the regional system, or vice versa.
The regional allocation of countries was generally as follows:[1] However, UEFA could make exceptions to these allocations to ensure an even number of teams in each region.
[2][3] Notes The draw for the first qualifying round was held on 24 June 2005.
[4] A total of 50 teams played in the first qualifying round.
Prior to the draw, UEFA divided the teams into three regions, with each region containing seeded and unseeded teams in accordance with the principles set by the Club Competitions Committee.
[5] Seeding of teams within each region was based on their 2005 UEFA club coefficients.
The draw for the second qualifying round was held on 29 July 2004.
Prior to the draw, UEFA divided the teams into three regions, with each region containing two groups of seeded and unseeded teams in accordance with the principles set by the Club Competitions Committee.
[8] Seeding of teams within each region was based on their 2005 UEFA club coefficients.
[2] Red Star Belgrade won 7–1 on aggregate.
2–2 on aggregate; Lokomotiv Plovdiv won on away goals.
3–3 on aggregate; Zenit Saint Petersburg won on away goals.