The 2005–06 UNC Wilmington Seahawks men's basketball team represented the University of North Carolina Wilmington during the 2005–06 NCAA Division I men's basketball season.

The Seahawks, led by fourth-year head coach Brad Brownell, played their home games at the Trask Coliseum and were members of the Colonial Athletic Association (CAA).

After finishing atop the CAA regular season standings, the Seahawks won the CAA tournament to receive an automatic bid to the NCAA tournament as No.

9 seed in the South region.

9 seed George Washington, 88–85 in OT, in the opening round.