The 2005–06 Ukrainian First League is the fifteenth since its establishment.
There were 20 teams competing.
Two teams were relegated from the 2004–05 Vyshcha Liha.
Four teams were promoted from the 2004–05 Ukrainian Second League.
In 2005-06 season, the Ukrainian First League consists of the following teams: These four teams were promoted from Druha Liha at the start of the season: Two teams were relegated from the Vyshcha Liha season: Statistics are taken from here.