The 2005 AFC Cup was the second edition of the AFC Cup, playing among clubs from nations who are members of the Asian Football Confederation.

The 'developing' 9 nations in the Asian Football Confederation were invited to nominate one or two clubs to participate in the 2005 competition.

Central & West Asia Al-Hussein (Irbid) (2003–04 Jordan League runners-up) East Asia Key to colors in group tables:

Three best runners-up qualify for the quarter-finals.

First leg Second leg First leg Second leg