Serena Williams defeated Lindsay Davenport in the final, 2–6, 6–3, 6–0 to win the women's singles tennis title at the 2005 Australian Open.

Williams saved three match points en route to the title, in the semifinals against Maria Sharapova.

Justine Henin-Hardenne was the reigning champion, but did not compete this year due to a knee injury.

This event marked the first major appearances for future world No.

Both reached the third round before losing to Amélie Mauresmo and Sharapova, respectively.