The team was coached by Tommy Bowden and played their homes game at Memorial Stadium in Clemson, South Carolina.

Clemson started off its season with wins over a ranked Texas A&M team and the Maryland Terrapins.

In the post-season, Clemson received an invitation to play in the 2005 Champs Sports Bowl against Colorado.

Clemson finished the season ranked in the top 25 (21st in both the AP and the Coaches' Poll) for the second time in three years.

Clemson also recorded wins against three AP top 20 teams in the 2005 season for just the fourth time in school history.