In a rematch of the 2004 final, the Free State Cheetahs reversed the result, coming from behind to defeat the Blue Bulls 29–25 and win their first Currie Cup since 1976.
All the teams played a single round of games within their section, meaning every team played six matches – three at home and three away.
The top four teams in each section qualified to the Premier Division, while the bottom three teams in each section qualified to the First Division.
The top two teams in each section qualified to the title play-offs, where the section winners would have home advantage against the runners-up.
The following table contain only points which have been scored in competitive games in the 2005 Currie Cup Premier Division:[80] The six teams that qualified to the First Division remained in the same sections (Section X and Section Y) as they were during the qualifying round.