The 2005 Michigan State Spartans football team represented Michigan State University in the 2005 NCAA Division I-A football season.

Michigan State competed as a member of the Big Ten Conference, and played their home games at Spartan Stadium in East Lansing, Michigan.

The Spartans were led by third-year head coach John L. Smith.

Roster The following players were selected in the 2006 NFL draft.

This college football 2000s season article is a stub.