The Wolverines played their home games at Michigan Stadium.

3 early in the season, Michigan did not lose a game by more than a touchdown and upset Penn State, who finished #3 in the nation, on a last second touchdown pass from Chad Henne to Mario Manningham.

The team earned an invitation to the 2005 Alamo Bowl, where it lost to the Nebraska Cornhuskers by a 32–28 margin.

The team's first five conference games were all decided in the final 24 seconds of regulation or in overtime.

During the three injury-affected games Michigan lost to Notre Dame and Wisconsin and slipped out of the polls for the first time since 1998, snapping the nation's longest streak of 114-straight poll appearances.