The 2005 US Open was the fourth and final Grand Slam of 2005.

Roger Federer was successful in defending his 2004 title, defeating Andre Agassi in the final.

Svetlana Kuznetsova was unsuccessful in her title defense, losing in the first round against compatriot Ekaterina Bychkova.

This was the first time that future US Open (Tennis) champion Andy Murray was featured in the tournament.

Roger Federer defeating Andre Agassi,[1] 6–3, 2–6, 7–6(1), 6–1 Kim Clijsters defeating Mary Pierce, 6–3, 6–1 Bob Bryan / Mike Bryan defeating Jonas Björkman / Max Mirnyi, 6–1, 6–4 Lisa Raymond / Samantha Stosur defeating Elena Dementieva / Flavia Pennetta, 6–2, 5–7, 6–3 Daniela Hantuchová[2] / Mahesh Bhupathi defeating Katarina Srebotnik / Nenad Zimonjić, 6–4, 6–2 Ryan Sweeting defeating Jérémy Chardy, 6–4, 6–4 Victoria Azarenka[3] defeating Alexa Glatch, 6–3, 6–4 Alex Clayton / Donald Young defeating Carsten Ball / Thiemo de Bakker, 7–6(3), 4–6, 7–5 Nikola Fraňková / Alisa Kleybanova defeating Alexa Glatch / Vania King, 7–5, 7–6(3) More information on the top 32 seeds here.