Following the regular season, the Hokies faced Atlantic Division champion Florida State in the ACC football championship game.

After a defensive struggle in the first half and a 3-3 halftime tie, Florida State broke the game open in the third quarter, piling up 24 unanswered points.

The Hokies concluded the season at the 2006 Gator Bowl against Louisville, scoring 22 unanswered fourth quarter points to defeat the #16 Cardinals 35–24.

Marcus Vick, who had seen limited action in 2003, before being suspended for the 2004 season for off-field transgressions,[49] entered spring practice as the #3 quarterback on the depth chart behind Sean Glennon and Cory Holt.

During the West Virginia game, Vick made an obscene gesture towards the Mountaineer fans who had been chanting "rapist" and "child molester" at him.

[52] Despite the incident, Vick was a near-perfect 15 of 17 passing against the Mountaineers and added 74 yards on the ground, including a 23-yard scramble as part of a fourth-quarter touchdown drive that would put the game out of reach.

Following the loss to Florida State in the ACC championship game, the Hokies earned a trip to the Gator Bowl to face Louisville.

During the second quarter of the game, as players were returning to the huddle after a play, Vick stomped on the left calf of Louisville defensive end Elvis Dumervil.

With third down and 3 yards to go from his own 8, Vick threw an incomplete pass and the Hokies would have had to punt, but an NC State personal foul allowed the drive to continue.

In the fourth quarter, after a 21-yard punt return by Eddie Royal, Tech found itself starting at the NC State 20 and Marcus Vick hit David Clowney for the winning touchdown.

Ohio's defense, which had scored two touchdowns the previous week in an upset win over Pitt, stifled the Hokies early, allowing only 158 first half yards and twice forcing three-and-out drives.

[63] In their only scoring threat of the first half, Ohio penetrated deep into Tech territory, but the drive stalled at the 20 and kicker Jonathon Greene missed a field goal.

[65] Georgia Tech quarterback Reggie Ball, who had missed the previous week's game against Connecticut due to viral meningitis was not 100%.

Louisville led for much of the game, beginning with an 11-yard touchdown pass in the first quarter by backup quarterback Hunter Cantwell, who filled in for the injured Brohm.