In their fifth season under head coach Jim Grobe, the Demon Deacons compiled a 4–7 record (3–5 in conference games), finished in fourth place in the Atlantic Division of the ACC, and were outscored by a total of 316 to 269.
[1] The team's statistical leaders included quarterbacks Ben Mauk (845 passing yars) and Cory Randolph (821 passing yards); Chris Barclay (1,127 rushing yards); Nate Morton (482 receiving yards); Sam Swank (86 points on 29 extra points and 19 field goals); Jon Abbate (77 total tackles); and Josh Gattis (46 solo tackles).
[2] Two Wake Forest players received first-team honors on the 2005 All-Atlantic Coast Conference football team: Barclay at running back and Plackemeier at punter.
Defensive back Josh Gattis was named ot the second team.
[3] The team played its home games at Groves Stadium in Winston-Salem, North Carolina.