Two-time defending champion Roger Federer defeated Andy Roddick in a rematch of the previous year's final, 6–2, 7–6(7–2), 6–4 to win the gentlemen's singles tennis title at the 2005 Wimbledon Championships.

Federer lost only one set during the tournament, to Nicolas Kiefer in the third round.

1, Olympic gold medalist and seven-time Wimbledon champion Novak Djokovic.

By reaching the third round, Djokovic entered the top 100 in the ATP rankings for the first time in his career.

He was replaced in the draw by the highest-ranked non-seeded player Olivier Rochus, who became the #33 seed.