The 2006–07 FIBA EuroCup Challenge was the fifth edition of Europe's fourth-tier level transnational competition for men's professional basketball clubs.

The Russian club CSK VVS-Samara won the title, after beating the Cypriot club Keravnos in the Final.

The quarterfinals were two-legged ties determined on aggregate score.

All return legs were played on January 18, 2007.

The quarterfinals were two-legged ties determined on aggregate score.