Following the enforced relegation, Juventus lost Fabio Cannavaro and Emerson to Real Madrid, Lilian Thuram and Gianluca Zambrotta to Barcelona, Adrian Mutu to Fiorentina, and Patrick Vieira and Zlatan Ibrahimović to Internazionale.

Other players stayed at the club, however, including Alessandro Del Piero, Gianluigi Buffon, Giorgio Chiellini, Pavel Nedvěd, David Trezeguet, Marcelo Zalayeta, and Mauro Camoranesi, for the following 2006–07 Serie B.

In July 2006, former player Didier Deschamps was announced as the new manager following the resignation of Fabio Capello, who left for Spanish club Real Madrid.

Against Albinoleffe, Buffon was shown the red card for the first time in his career and conceded a penalty, but a 10-man Juve team managed to draw the game.

On Matchday 40, Juventus were then crowned Serie B champions following a 2–0 home win to Mantova On 26 May, it was confirmed that Deschamps had resigned as manager due to differences with the club hierarchy, especially director of football Alessio Secco.