New teams to the division included Bradford & Bingley (champions) and Nuneaton (playoffs) who were promoted from the 2005–06 National Division Three North, Cambridge who came up from the 2005–06 National Division Three South and no new teams joined from the previous season's National Division One due to the RFU's decision to expand that league from 14 to 16 teams and ending relegation for that season alone.

[1][2][3][4][5] At the end of the season Esher were the clear league winners, beating second place Launceston to the title by 9 points and defeating the Cornish side home and away, with both sides being promoted to the 2007–08 National Division One.

[6][7] Relegated teams included Harrogate, Barking and newly promoted Bradford & Bingley.

All three sides finished well below 11th placed Halifax with Harrogate only winning one game all season.

107 - 5 Cambridge at home to Harrogate on 28 April 2007 70 - 15 Manchester away to Barking on 14 April 2007 107 - 5 Cambridge at home to Harrogate on 28 April 2007 Cambridge at home to Harrogate on 28 April 2007 Cambridge at home to Harrogate on 28 April 2007 Esher away to Stourbridge on 3 February 2007 Henley Hawks away to Halifax on 31 March 2007 Henley Hawks away to Esher on 21 April 2007 [18][19][20][21] Alastair Bressington for Stourbridge away to Bradford & Bingley on 23 September 2006 Neil Hallett for Esher away to Blackheath on 11 November 2006 Christoff Lombaard for Cambridge at home to Harrogate on 28 April 2007 Dafydd Lewis for Cambridge at home to Harrogate on 28 April 2007 Neil Hallett for Esher away to Stourbridge on 3 February 2007 Mitch Burton for Henley Hawks away to Halifax on 31 March 2007 Mitch Burton for Henley Hawks away to Esher on 21 April 2007 [22][23][24][25][26] Esher at home to Henley Hawks on 21 April 2007 Barking at home to Henley Hawks on 21 October 2006 Redruth Barking [27]