The 2006–07 Quaid-e-Azam Trophy was one of three first-class domestic cricket competitions that were held in Pakistan during the 2006–07 season.

The Quaid-e-Azam Trophy was contested by thirteen teams representing regional associations;[a] it was preceded in the schedule by the Patron's Trophy (Grade-I), contested by nine departmental teams,[a] and followed later in the season by the Pentangular Cup, which unlike the previous year did not involve teams from the Quaid-e-Azam Trophy.

Karachi Urban lifted the Quaid-e-Azam Trophy, the eighteenth victory by a Karachi team, after they beat defending champions Sialkot by eight wickets in the Gold League final.

[4] Multan won the Silver League final in a replay,[5] after the weather-affected first match ended in a draw with no result on first innings.

[6] The top two teams in the round-robin group stage (highlighted) advanced to the finals.