The knockout stage of the 2006–07 UEFA Cup began on 14 February 2007, culminating with the final at Hampden Park, Glasgow, on 16 May 2007.
The knockout stage included the top three teams from each group in the previous stage and the third-placed teams from the 2006–07 UEFA Champions League group stage.
Each knockout round tie consisted of two-legged matches, home and away, in which the team with the higher aggregate score progressed to the next round, with the exception of the final, which was played over just one match at a neutral venue.
In the event that the two teams' aggregate scores were tied, the team that scored more goals in their away leg would progress to the next round.
Tottenham Hotspur won on walkover after Feyenoord were disqualified.
The draw for the final stages, included quarter-finals and semi-finals, was held on 16 March 2007 in Glasgow, Scotland.
The semi-final matches were played on 26 April and 3 May 2007.
The final was played on 16 May 2008 at Hampden Park in Glasgow, Scotland.