The 2006 AFC Champions League Final was a two-legged football tie to determine the 2006 champions of Asian club football.

South Korean club Jeonbuk Hyundai Motors defeated Syrian representative Al-Karamah 3–2 on aggregate to take the title.

[1] As of 2022, this was the only final of an AFC Champions League involving a Syrian club.

The first leg took place on 1 November 2006 at 19:00 local time (UTC+9) at Jeonju World Cup Stadium in Jeonju, which Jeonbuk Hyundai Motors won 2–0.

The second leg took place on 8 November 2006 at 20:00 local time (UTC+3) at Khaled bin Walid Stadium, Homs, which Al-Karamah took 2–1.