Based on a favorable schedule featuring the most difficult opponents in home games and with returning starters Brandon Cox at quarterback and Heisman Award-candidate Kenny Irons at tailback, Auburn was predicted to be in contention for a BCS bowl and possible national championship.

Prior to the season, Auburn switched uniform providers, ending its long association with Russell Athletic for a new agreement with UnderArmour.

In the second quarter, Auburn scored on each of its three possessions, including two more field goals and a Brad Lester touchdown to take a 19–7 lead to the locker room at halftime.

Auburn held Jason Hill to only four receptions for 18 yards and intercepted Brink once to hold the Cougs potent offense in check.

Auburn traveled to Starkville for the fifteenth time to meet SEC-West foe Mississippi State under the direction of third-year coach Sylvester Croom.

Kicker John Vaughn had a career-long 55-yard field goal and tailback Brad Lester added 41 yards rushing and two touchdowns to the offensive team effort to help Auburn to a 34–0 shutout over the Bulldogs.

The Bulls, under head coach and former Nebraska star quarterback Turner Gill, played inspired football against the banged-up Tigers keeping the game close until late in the third quarter.

Auburn running back Kenny Irons, who began his college football career at South Carolina, rushed for 117 yards and scored two touchdowns as the third-ranked Tigers survived a furious comeback by the upset-minded Gamecocks and posted a 24–17 victory.

Freshman quarterback Mitch Mustain's 50-yard touchdown pass to Monk in the first quarter set the tone for the Hogs, who won at Auburn for the third time since they joined the SEC in 1992.

Although the Green Wave entered the game leading the all-time series record 17–13–6, that success dates from the early twentieth-century, when Tulane was a football powerhouse.

With their top three running backs hobbled by injuries, quarterback Brandon Cox and true freshman tailback Ben Tate both stepped up with strong performances and to end Auburn's seven-quarter offensive touchdown drought.

Tulane responded with an 80-yard touchdown driver of their own capped off by a 23-yard TD pass from Lester Ricard to Damarcus Davis with just over six minutes left in the first quarter.

The teams traded field goals just before halftime and then Auburn pulled away with two more touchdowns in the third quarter before taking a knee on Tulane's 10-yard line to run out the clock and end the game.

Auburn answered with their scoring drive ending in 13-yard TD pass from Brandon Cox to wide receiver Rodgeriqus Smith.

After an incompletion to open the drive, Auburn abandoned the passing game and let tailback Kenny Irons pound out the yardage and burn the clock.

The Tigers drove to the Ole Miss 12 yd line before settling for a final field goal with only 35 seconds left to make the score 23–17.

With no timeouts remaining and paying little attention to the new clock rules, Ole Miss could only manage one play as Schaeffer was sacked due to the Auburn coverage.

Auburn held Arkansas State out of the Sun Belt Conference to 177 yards total offense as the Tigers shut out the Indians 27–0.

Courtney Taylor caught four passes for 116 yards, including a 13-yard reception for a touchdown, and the Tigers improved their all-time record against teams currently in the Sun Belt Conference to 12–0.

In one of the biggest upsets in the history of the Deep South's Oldest Rivalry, Georgia completely dominated Auburn and took a convincing 37–15 win over the #5 ranked Tigers.

Two fumble recoveries deep in Alabama territory in the second quarter forced by Auburn's Quentin Groves enabled the Tigers to score touchdowns on short drives.

Alabama pulled to within five points late in the first half on a 52-yard touchdown pass from John Parker Wilson to Nikita Stover, making the score 14–9 at halftime.

A halfback option pass from Auburn's Carl Stewart to Lee Guess for a successful two-point conversion provided the final margin.

The Tigers played the Cotton Bowl Classic without three players whose suspensions were announced by head coach Tommy Tuberville in December: linebackers Kevin Sears and Tray Blackmon, and running back Brad Lester.