[1] Sporting Praia won their 5th title and in the following year participated in the 2007 CAF Champions League.
Three clubs returned again, FC Derby, Sporting Praia and Mindelense, some others returned in some or several years, two clubs Barreirense FC and Beira Mar competed for the first time.
A total of 11 clubs participated in the competition, one from each island league and one who won the last season's title.
The Santiago Island League North Zone had no championships for the 2005-06 season.
The season marked the last appearance of Nô Pintcha at the nationals, a club who won a lot of regional title at the time.