The Copa Mustang I 2006 was the first tournament of the 2006 season of Fútbol Profesional Colombiano, first division in Colombian football.
It began on the night of July 15, 2006 with the opening match between Atlético Nacional and Cúcuta Deportivo in Medellín at the stadium Estadio Atanasio Girardot.
In the league stage, last year's Finalización champions Deportivo Cali were knocked out after a last-round defeat to Independiente Medellín, while Envigado FC were relegated to Primera B after losing 12 of their 18 games, thus ending with the worst point average.
América de Cali played its worst season, losing 11 matches and struggling at the bottom of the table.
The champions were Cúcuta Deportivo defeating Deportes Tolima in the finals with the total aggregate score of 2-1 from two matches.